Gynecomastia
Afimoxifene (4-OHT) gel will be investigated as a treatment for gynecomastia, the overdevelopment of breast tissue in males, and associated breast pain. Boys or men with gynecomastia experience swelling in the glandular breast tissue due to an excess of estrogen or a lack of testosterone.
Gynecomastia can bring feelings of shame, embarrassment, and humiliation to the estimated 40 to 60% of males that it affects. Males with gynecomastia have large, female-like breasts, which can impede swimming or other activities where their breasts might be seen.